Neuroimmunology: Potential for Novel Therapeutics for CNS Disorders
The successes of therapeutics targeting inflammatory mechanisms in relapsing and remitting multiple sclerosis have led to neuroimmunology emerging as an important new paradigm in central nervous system (CNS) disorders.1 In neurodegenerative disorders like Alzheimer’s disease and Parkinson’s disease, human disease genetics strongly implicate several inflammatory pathways such as microglial signaling and complement.2 Moreover, recent research implicates inflammation in psychiatric disorders such as schizophrenia and major depressive disorder.3
The field holds great promise for the development of impactful novel therapeutics to treat several CNS disorders of high unmet medical need. Current challenges focus on generating robust therapeutic hypotheses for neuroinflammatory disorders, patient stratification and drug discovery challenges to develop safe CNS penetrant molecules. However, new data emerging from advanced genomics and big data analytics is helping the field better understand the challenges and navigate the roles of various inflammatory processes in several CNS indications. This research is bolstered by exciting findings from human cell and preclinical transgenic models, enabling further detailed understanding of disease biology.
尽管CNS疾病的复杂性挫败了过去的制药公司投资，但充满活力的投资者环境现在正在为令人兴奋的新公司提供针对一系列神经免疫学目标的药物发现计划。鉴于该领域的进步，Johnson＆Johnson Innovation与Janssen Neuroscience合作，正在寻求收集行业领先的企业家，生物技术和学术研究人员，以讨论利用Neuroummummumnologology中的下一波科学和创新浪潮。
- Dobson and Giovannoni Eur J Neurol. 2019 26: 27-40
- Crehan et al. 2012. Int J Alzheimer Dis doi: 10.1155/2012/983640
- Bauer and Teixeira 2021 Neuroimmunomodulation doi: 10.1159/000515594
Please note that this webinar was originally run on 06/30/2021.
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